The best museums in Santa Ana in September 2025

These are the top 10 best museums in Santa Ana, United States, ranked by their rating and popularity in 2025. Click a museum for more information about the museum, including visitor information, exhibitions and reviews.

For a complete overview of museums in Santa Ana, their exhibitions and discount cards & passes, see our overview page with all museums in Santa Ana.

Looking for the best museums in Santa Ana? These are the best ones:

  1. Discovery Cube Orange County1

    Discovery Cube Orange County

     Santa Ana, CA
    The Discovery Cube Orange County, located in Santa Ana, California, is a science museum that was previously known as the Discovery Science Center and the Taco Bell Discovery Science Center. The museum is home to over 100 hands-on science exhibits that are designed to ignite the natural curiosity of children. These interactive exhibits provide an engaging and educational experience for visitors of all ages.
  2. Discovery Cube2

    Discovery Cube

     Santa Ana, CA
    The Discovery Cube Orange County, previously known as the Discovery Science Center and the Taco Bell Discovery Science Center, is a science museum located in Santa Ana, California. The museum is home to over 100 interactive science exhibits that are designed to ignite the natural curiosity of children. These exhibits provide a hands-on learning experience, making science fun and engaging for all ages.
  3. Lyon Air Museum3

    Lyon Air Museum

     Santa Ana, CA
    The Lyon Air Museum is an aerospace museum situated on the west side of the John Wayne Airport in Santa Ana, California, United States. This location makes it easily accessible for tourists traveling by air, as it is conveniently located near a major airport.
  4. Old Orange County Courthouse4

    Old Orange County Courthouse

     Santa Ana, CA
    The Old Orange County Courthouse, also known as the Santa Ana County Courthouse, is a historic building that was opened in September 1901. It is located in Santa Ana's Historic Downtown District on Civic Center and Broadway streets. The building is a fine example of Romanesque Revival architecture, which adds to its historical significance.
  5. Santa Ana Zoo At Prentice Park5

    Santa Ana Zoo At Prentice Park

     Santa Ana, CA
    The Santa Ana Zoo at Prentice Park is a 20-acre zoo located in Santa Ana, California. The zoo primarily focuses on the animals and plants of Central and South America, providing a unique opportunity for visitors to learn about and experience the diverse wildlife of these regions.
  6. CSUF Grand Central Art Center6

    CSUF Grand Central Art Center

     Santa Ana, CA
  7. Bowers Museum7

    Bowers Museum

     Santa Ana, CA
    The Bowers Museum, situated in Santa Ana, California, is an art museum that boasts a permanent collection of more than 100,000 objects. This vast collection spans various regions and periods, offering visitors a comprehensive look into the world of art and culture.
  8. El Centro Cultural De México8

    El Centro Cultural De México

     Santa Ana, CA
    El Centro Cultural de México, located in Santa Ana, Orange County, California, is a volunteer-run space that focuses on transnational projects. These projects aim to connect residents with communities across Mexico through arts, culture, and social justice initiatives.
  9. Howe-waffle House and Medical Museum9

    Howe-waffle House and Medical Museum

     Santa Ana, CA
    The Howe-Waffle House and Medical Museum is a historical site located in Santa Ana, California. This Queen Anne style home, built in 1889, was the residence of Dr. Willella Howe-Waffle, a pioneer in the medical field as one of the first female physicians in Orange County, California. She lived in this house until her death in 1924.
  10. 10

    Heritage Museum of Orange County

     Santa Ana, CA
    Amazingly well-preserved historical mansion, full of interesting exhibits and neat furnishings. Come here to learn more about the past!

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