The best museums in Greenville in September 2025

These are the top 10 best museums in Greenville, United States, ranked by their rating and popularity in 2025. Click a museum for more information about the museum, including visitor information, exhibitions and reviews.

For a complete overview of museums in Greenville, their exhibitions and discount cards & passes, see our overview page with all museums in Greenville.

Looking for the best museums in Greenville? These are the best ones:

  1. Greenville Zoo1

    Greenville Zoo

     Greenville, SC
  2. Bob Jones University Museum & Gallery2

    Bob Jones University Museum & Gallery

     Greenville, SC
    The Museum & Gallery, Inc. specializes in sacred art, with a primary focus on European Old Master paintings. However, the museum also houses smaller collections of sculpture, furniture, architectural elements, textiles, Greek and Russian icons, and ancient artifacts. This diverse collection offers a comprehensive view of various art forms and historical periods.
  3. Kilgore-Lewis House3

    Kilgore-Lewis House

     Greenville, SC
    The Kilgore-Lewis House, originally known as the Josiah Kilgore House, is a historic home situated in Greenville, South Carolina. This house, built around 1838, carries a significant historical value and is a notable landmark in the region. It offers a glimpse into the architectural style of the period, making it an interesting destination for those interested in history and architecture.
  4. Greenville County Museum of Art4

    Greenville County Museum of Art

     Greenville, SC
    The Greenville County Museum of Art, located in Greenville, South Carolina, primarily focuses on American art. The museum's collection includes works by renowned artists such as Andrew Wyeth, Josef Albers, Jasper Johns, Andy Warhol, Romare Bearden, Jacob Lawrence, Ronnie Landfield, Helen Turner, Mary Tannahill, Eric Fischl, Marylyn Dintenfass, and Leon Golub. Jasper Johns, a notable figure in the collection, was raised in South Carolina, adding a local touch to the museum's offerings.
  5. 5

    Museum and Library of Confederate History

     Greenville, SC
  6. Upcountry History Museum6

    Upcountry History Museum

     Greenville, SC
    The Upcountry History Museum, located in Greenville, South Carolina, is a unique institution that showcases the regional history of fifteen upstate South Carolina counties. The museum's exhibits span from the early 18th century to the present, providing a comprehensive view of the area's past. Visitors can gain a deeper understanding of the region's history and how it has shaped the present.
  7. 7

    Roper Mountain Science Center

     Greenville, SC
    The Roper Mountain Science Center, situated in Greenville, South Carolina, is a unique establishment that offers a variety of facilities for studying life and natural sciences, space, and physical sciences. It is part of the Greenville County School District, making it an integral part of the local educational infrastructure. The center was initiated through a unique partnership between public and private resources, with planning starting in 1982 and the center officially opening in 1985.
  8. 8

    The Children's Museum of the Upstate

     Greenville, SC
  9. 9

    Sigal Music Museum

     Greenville, SC
  10. 10

    Greenville Cultural Exchange Center

     Greenville, SC

All museums in Greenville