The best museums in St. Joseph in September 2025

These are the top 5 best museums in St. Joseph, United States, ranked by their rating and popularity in 2025. Click a museum for more information about the museum, including visitor information, exhibitions and reviews.

For a complete overview of museums in St. Joseph, their exhibitions and discount cards & passes, see our overview page with all museums in St. Joseph.

Looking for the best museums in St. Joseph? These are the best ones:

  1. Glore Psychiatric Museum1

    Glore Psychiatric Museum

     St. Joseph, MO
    The exhibits at the Glore Psychiatric Museum provide a comprehensive look at the 130-year history of the adjacent state mental hospital. They also illustrate the evolution of mental health treatment throughout history. This offers visitors a unique opportunity to learn about the progression of mental health care.
  2. Patee House Museum And Jesse James Homes2

    Patee House Museum And Jesse James Homes

     St. Joseph, MO
    The Patee House, also known as the Patee House Museum, is a historic site located at 12th Street and Penn in St. Joseph, Missouri. Completed in 1858, it was originally a 140-room luxury hotel and was one of the best-known hotels west of the Mississippi River. The museum offers a glimpse into the past, showcasing the grandeur of the 19th-century hotel industry.
  3. 3

    Jesse James Home

     St. Joseph, MO
    The Jesse James Home Museum is a significant historical site in St. Joseph, Missouri. This is the very house where the infamous outlaw Jesse James resided and was fatally shot by Robert Ford on April 3, 1882. The event marked a pivotal moment in American history, making this location a point of interest for those keen on understanding the life and times of Jesse James.
  4. 4

    Remington Nature Center

     St. Joseph, MO
  5. 5

    Wyeth-tootle Mansion

     St. Joseph, MO

All museums in St. Joseph