The best museums in Siena in September 2025

These are the top 10 best museums in Siena, Italy, ranked by their rating and popularity in 2025. Click a museum for more information about the museum, including visitor information, exhibitions and reviews.

For a complete overview of museums in Siena, their exhibitions and discount cards & passes, see our overview page with all museums in Siena.

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Looking for the best museums in Siena? These are the best ones:

  1. 1

    Siena Cathedral

     Siena
    The exterior and interior of Siena Cathedral are adorned with white and greenish marble, forming characteristic horizontal stripes. These colors, white and black, are symbolic of Siena, taken from the white and black horses of the city's legendary founders, Senio and Asquio. This unique design element adds to the cathedral's aesthetic appeal and is a notable feature for visitors to observe.
  2. Palazzo Pubblico2

    Palazzo Pubblico

     Siena
    The Palazzo Pubblico is a significant civil monument in Siena, with its construction dating back to the late 13th century and completion in the mid-14th century. The building is a prime example of Sienese Gothic architecture. It is situated at the lower end of the Piazza del Campo, Siena's central square, which is also the venue for the biannual Palio horse race.
  3. Piccolomini Library3

    Piccolomini Library

     Siena
    The Piccolomini Library, located within the Siena Cathedral, is a significant historical site dedicated to the life of Pope Pius II. The library was established by his nephew, Cardinal Francesco Piccolomini, who was also the Bishop of Siena. The library houses precious book collections of the humanist Pope, Enea Silvio Piccolomini, who passed away in 1464. The library's entrance is from within the cathedral itself.
  4. Santa Maria della Scala, Siena4

    Santa Maria della Scala, Siena

     Siena
    The Santa Maria della Scala museum complex is a collection of museums in Siena, Italy. These museums are located within the Santa Maria della Scala Hospital, which is accessible from the forecourt of the Duomo. This location makes it a convenient stop for tourists visiting the Duomo and looking to explore more of Siena's rich history and culture.
  5. Piccolomini Palace5

    Piccolomini Palace

     Siena
    The Palazzo Piccolomini, also known as Palazzo Todeschini Piccolomini, is a Renaissance-style city palace located in Siena. This grand structure served as the main residence of the Piccolomini noble family. Its architectural style and historical significance make it a notable point of interest for visitors to the city.
  6. National Picture Gallery of Siena6

    National Picture Gallery of Siena

     Siena
  7. Museo dell'Opera del Duomo (Siena)7

    Museo dell'Opera del Duomo (Siena)

     Siena
    The Museo dell'Opera Metropolitana del Duomo is a museum located in Siena, Italy. It is dedicated to preserving the works of various artists who have contributed to the city's rich cultural and artistic heritage over the centuries. These works were created for the dome, baptistery, and oratory of San Bernardino, some of the city's most significant architectural landmarks.
  8. Orto Botanico dell'Università di Siena8

    Orto Botanico dell'Università di Siena

     Siena
    The Botanical Garden of the University of Siena, also known as Orto Botanico dell'Università di Siena, is a botanical garden that spans across 2.6 hectares. It is situated in the beautiful city of Siena, Italy. This garden is a part of the university and is a member of the Botanic Gardens Conservation International (BGCI).
  9. Natural History Museum of the Academy of the Fisiocritici9

    Natural History Museum of the Academy of the Fisiocritici

     Siena
    The Natural History Museum of the Academy of the Fisiocritici, also known as MUSNAF, is an integral part of the Academy. It is housed in the former convent of Santa Mustiola, a building that dates back to the 12th century and once belonged to the Camaldolese order. The museum has been located here since 1816, adding a layer of historical significance to its scientific collections.
  10. State Archives of Siena10

    State Archives of Siena

     Siena
    The State Archives of Siena, known as Archivio di Stato di Siena in Italian, is housed in the historic Palazzo Piccolomini. This location adds a layer of historical significance to the archives, as the Palazzo Piccolomini itself is a notable landmark in Siena. Visitors to the archives will not only have the opportunity to explore the vast collection of documents but also appreciate the architectural beauty of the Palazzo.

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