The best museums in Durham in September 2025

These are the top 5 best museums in Durham, United States, ranked by their rating and popularity in 2025. Click a museum for more information about the museum, including visitor information, exhibitions and reviews.

For a complete overview of museums in Durham, their exhibitions and discount cards & passes, see our overview page with all museums in Durham.

Looking for the best museums in Durham? These are the best ones:

  1. Duke Lemur Center1

    Duke Lemur Center

     Durham, NC
    The Duke Lemur Center, located at Duke University in Durham, North Carolina, is an 85-acre sanctuary for rare and endangered strepsirrhine primates. It holds the distinction of being the largest sanctuary for these primates in the world.
  2. Duke Gardens2

    Duke Gardens

     Durham, NC
    The Sarah P. Duke Gardens are a significant part of Duke University in Durham, North Carolina. Covering approximately 55 acres, these gardens offer a vast expanse of landscaped and wooded areas for visitors to explore. The gardens provide a serene environment that contrasts with the bustling university environment, making it a perfect spot for relaxation and nature appreciation.
  3. Museum of Life and Science3

    Museum of Life and Science

     Durham, NC
    The Museum of Life and Science, which was previously known as the North Carolina Museum of Life and Science and the NC Children's Museum, is a large science museum located in Durham, North Carolina. The museum spans an impressive 84 acres and offers a variety of exhibits and activities for visitors of all ages.
  4. Nasher Museum of Art4

    Nasher Museum of Art

     Durham, NC
    The Nasher Museum of Art, previously known as the Duke University Museum of Art, is situated on the campus of Duke University in Durham, North Carolina. This museum is a significant part of the university and offers a rich collection of art for visitors to explore.
  5. Duke Homestead5

    Duke Homestead

     Durham, NC
    The Duke Homestead State Historic Site is a recognized state historic site and National Historic Landmark located in Durham, North Carolina. This site is significant as it commemorates the place where Washington Duke, a prominent figure in the American tobacco industry, founded the nation's largest early-20th-century tobacco firm, the American Tobacco Company. The site offers a glimpse into the history of the tobacco industry in the United States.

All museums in Durham