The best museums in Cheyenne in September 2025

These are the top 5 best museums in Cheyenne, United States, ranked by their rating and popularity in 2025. Click a museum for more information about the museum, including visitor information, exhibitions and reviews.

For a complete overview of museums in Cheyenne, their exhibitions and discount cards & passes, see our overview page with all museums in Cheyenne.

Looking for the best museums in Cheyenne? These are the best ones:

  1. Cheyenne Depot Museum1

    Cheyenne Depot Museum

     Cheyenne, WY
    The Cheyenne Union Pacific Railroad Depot, which now serves as a railway museum, was constructed between the years 1886 and 1887. This historic building was built from sandstone blocks sourced from Fort Collins, Colorado. Its location directly across the street from the Wyoming State Capitol signifies its historical importance in the city and state.
  2. Quebec 01 Missile Alert Facility2

    Quebec 01 Missile Alert Facility

     Cheyenne, WY
    The Quebec-One Missile Alert Facility, also known as Quebec-01 or Q-01, is a significant historical site located 30 miles north of Cheyenne, Wyoming, near Chugwater. This location offers visitors a unique opportunity to explore a piece of Cold War history in the United States.
  3. Wyoming State Museum3

    Wyoming State Museum

     Cheyenne, WY
    The Wyoming State Museum, located in Cheyenne, Wyoming, is a state-run institution that was established in 1895. This museum is a testament to the rich history and cultural heritage of the state, offering visitors a glimpse into the past.
  4. 4

    Cheyenne Frontier Days Old West Museum

     Cheyenne, WY
    The Cheyenne Frontier Days Old West Museum, founded in 1978, is situated in Cheyenne, Wyoming, United States. This museum is a significant cultural institution that provides a deep dive into the history and culture of the American West, the state of Wyoming, and the city of Cheyenne.
  5. 5

    Nelson Museum of the West

     Cheyenne, WY
    Touches upon everything Western - from the animals through the horse saddles to the Native American artefacts. Wyoming in a nutshell.

All museums in Cheyenne